Telmefixx Plus Dosage/Direction for Use

Adults: Telmisartan + Amlodipine besilate should be taken once daily.
Replacement therapy: Patients receiving Telmisartan and Amlodipine besilate from separate tablets can instead receive Telmisartan + Amlodipine besilate containing the same component doses in one tablet once daily, e.g., to enhance convenience or compliance.
Add-on therapy: Telmisartan + Amlodipine besilate may be administered in patients whose blood pressure is not adequately controlled with Amlodipine or Telmisartan alone.
Patients treated with 10 mg Amlodipine who experience any dose-limiting adverse reactions such as edema, may be switched to Telmisartan + Amlodipine besilate 40 mg/5 mg once daily, reducing the dose of Amlodipine without reducing the overall expected antihypertensive response.
Initial therapy: A patient may be initiated on Telmisartan + Amlodipine besilate if it is unlikely that control of blood pressure would be achieved with a single agent. The usual starting dose of Telmisartan + Amlodipine besilate is 40 mg/5 mg once daily. Patients requiring larger blood pressure reductions may be started on Telmisartan + Amlodipine besilate 80 mg/5 mg once daily.
If additional blood pressure lowering is needed after at least 2 weeks of therapy, the dose may be titrated up to a maximum of 80 mg/10 mg once daily.
Telmisartan + Amlodipine besilate can be administered with other antihypertensive drugs.
Special populations: Renal impairment: No posology adjustment is required for patients with renal impairment, including those on hemodialysis. Amlodipine and Telmisartan are not dialyzable.
Hepatic impairment: In patients with mild to moderate hepatic impairment, Telmisartan + Amlodipine besilate should be administered with caution. For Telmisartan, the posology should not exceed 40 mg once daily.
Elderly: No dose adjustment is necessary for elderly patients.
Pediatric population: Telmisartan + Amlodipine besilate is not recommended for use in patients aged below 18 years due to a lack of data on safety and efficacy.
Method of Administration: Tablet for oral administration: Telmisartan + Amlodipine besilate may be taken with or without food.
Or as prescribed by the physician.